Demon Hashirama Cells???

"Senior Orochimaru, I learned a great deal of ancient history from the Slug Sage. For example, before the Ninjutsu Sect was founded and the Sage of Six Paths spread chakra throughout the ninja world, this world was home to all kinds of powerful creatures. They each had different ways of using natural energy. The sages of the Three Great Sage Regions, for instance, have existed in the ninja world since that era." "They can use Natural Energy, and humans can likewise find their own ways to use it.